See also: New and Experimental HIV Drugs and Treatments

Note: Salvage treatment is sometimes also called “Rescue Therapy” or “Third-Line Therapy.”

General Information

• Salvage Therapy (AIDS InfoNet) and Spanish version
• Is My Treatment Regimen Working? (AIDSInfo)
• HIV Treatment Failure (AIDSInfo)
• Management of the Treatment-Experienced Patient: Virologic Failure (from the U.S. Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents)
• Changing an HIV Treatment Regimen (AIDSInfo)
• Third Line/Rescue HIV Treatment (TheBody) – web page with links to fact sheets and articles

Selected Recent Articles

• Patients who fail modern HIV regimens show high prevalence of older mutations.  (December 2016, Hepmag)
• Most patients taking second-line ART in sub-Saharan Africa achieve viral suppression but there’s a need for third-line treatment options.  (August 2016, AIDSmap)
• Integrase Inhibitors Work Well to Treat NNRTI Drug Resistant HIV.  (July 2016, Beta Blog)
• It’s OK for HIV Salvage Regimens to Nix Nukes.  (January 2016, Poz)
• HIV salvage regimens can safely omit NRTIs, says US study.  (January 2016, AIDSmap)
• Costs Spike for 2nd- and 3rd-Line ARVs and Late Treatment.  (September 2013, Poz)
• New integrase inhibitor dolutegravir helps treatment-experienced people on failing therapy.  (March 2013, AIDSmap)
• Can people with resistant HIV omit NRTIs when switching from a failing regimen?  (March 2013, AIDSmap)
• HIV Meds Can Still Benefit Those with Triple-Class Failure.  (January 2013, Poz)
• Australian researchers project that many HIV-positive people will run out of treatment options.  (January 2013, AIDSmap)
• Any reduction in viral load has immunologic benefits for people with HIV who have triple-class treatment failure.  (January 2013, AIDSmap)